Khetwadi was a sparsely populated agricultural settlement until the early 19th century; it developed into a major residential region after the widening of Parel Road and the Girgaom Road and the completion of the Grand Road, which lead to large-scale migrations to this part of the city. Now, Khetwadi is one of the most populated regions in Mumbai.

Thakurdwar Temple and Kalbadevi temple are two famous shrines in the neighborhood.

Chhatrapati Shivaji International Airport is 22 km north. Nearest major railhead is Mumbai Central Railway Station. Chhatrapati Shivaji Terminus Railway Station is around 3 km south.