Musafirkhana is about 32 km north-west of Sultanpur, 27 km from Nihalgarh and 20 km from Jagdishpur. It is also connected by road to Gauriganj and Amethi.

Amethi railway station, situated on the Lucknow-Varanasi rail route via Rae Bareli, serves Musafirkhana. The nearest airport is Amausi Airport.