Betel Vine is raised as tropical climate crops. It is commonly found in the uplands as well as in wetlands, but it is very sensitive to waterlogged, saline and alkali soils. Betel vine is also grown as an intercrop in areca nut and coconut groves.
Extremely low atmospheric temperature and hot dry winds are harmful to this crop. Improved varieties include Thulasi, Venmani, Arikodi, Kalkodi, Karilanchi, Karpuram, Chelanthikarpuram, Koottakkodinandan, Perumkodi, Amaravila and Pramuttan.